Cardinals vs 49ers

Cardinals vs 49ers played on September 21, 2025. Final score: Cardinals 15 - 49ers 16. Week 3. Fan ratings and discussion on RateGame.

Top fan take from @buckeyesforthenatty: “EDDY PIÑEIRO YOU ARE A SAN FRANSISCO 49ER #NFCWESTLEADER WE ARE 3-0 SHADOWS OF SUPER BOWL 58”

Venue: Levi's Stadium