Jaguars vs 49ers

Jaguars vs 49ers played on September 28, 2025. Final score: Jaguars 26 - 49ers 21. Week 4. Fan ratings and discussion on RateGame.

Top fan take from @nationalryanleague: “Pretty surprising but they knew exactly where to attack and it was amazing. Wish that could be leaned on more in matchups. Mac Jones could have took this loss for them.”

Venue: Levi's Stadium